I smoke beef roasts more than any other types and cuts of meats as being it is a slow cooked meat. Doing roasts every way possible, from a shredded beef to a prime rib style steak or even a true BBQ sauced up piece of meat. As for "Pot Roast" is not a specific cut but how you cook it, going for that style of cooked, but getting the smoked flavor, two methods I suggest, is either a couple hours smoke followed by the Pot or Crockpot, or smoke and wrap in foil with some fluid (I like a duck fat, brisket trimming, or butter based mixed with an 1/4 cup IPA and garlic). Or complete left field, salt the meat, coat in tzatziki sauce marinate 8 hours, cover in Slap your MaMa and cayenne pepper, smoke 6 hours at 200, coat in an apple BBQ sauce, smoke two more hours (don't continue to mop), foil for 30 minutes more in the smoker, let rest for 30 minutes still in the foil. I say times, but all depends on the actual type of Roast and size. But served with potatoes done your choice, and a veggies, today serving with over the top Brussel spots from the smoker also and mashed potatoes.